Reta GLP-3

• Multi-receptor binding and activation studies across GLP-1, GIP, and glucagon receptors
• Comparative pharmacology of single vs. multi-agonist peptides
• Signal transduction pathway characterization in cell-based assays
• Structure-activity relationship (SAR) analysis of peptide modifications
• Receptor selectivity profiling and cross-reactivity studies
• In vitro metabolic signaling pathway investigation
• Peptide stability and proteolytic resistance research

• Storage (Lyophilized): Store at -20°C in original sealed vial. Protect from light and moisture.
• Storage (Reconstituted): Store at 2-8°C for up to 14 days. For extended storage, prepare single-use aliquots and store at -20°C or -80°C. Avoid repeated freeze-thaw cycles.
• Reconstitution: Reconstitute with sterile water or sterile PBS using aseptic technique. Allow to dissolve completely without vigorous agitation.
• Stability: Lyophilized peptide stable for 24 months when stored at -20°C as directed.
• Handling: Wear appropriate personal protective equipment. Handle according to standard laboratory safety protocols for synthetic peptides.

Research Context: This compound serves as a reference material for investigating multi-agonist approaches in receptor pharmacology and comparative studies of incretin-based peptides.

Reconstitution Guidelines: Typical working concentrations range from 0.1-10 μM depending on assay design and experimental objectives. Addition of 0.1% BSA may minimize peptide adsorption to laboratory plasticware.

Structural Features: Engineered peptide sequence incorporating structural modifications to achieve balanced tri-agonist activity while maintaining proteolytic stability and receptor binding affinity.

Mechanism: This synthetic peptide exhibits agonist activity at three distinct G protein-coupled receptors: glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR).